Pediatric MLBL: challenges remain.
نویسندگان
چکیده
In this issue of Blood, Gerrard et al report the outcome and histologic classification of children and adolescents with mediastinal large B-cell lymphoma (MLBL), and highlight the need for new treatment strategies.
منابع مشابه
Outcome and pathologic classification of children and adolescents with mediastinal large B-cell lymphoma treated with FAB/LMB96 mature B-NHL therapy.
Mediastinal large B-cell lymphoma (MLBL) represents 2% of mature B-cell non-Hodgkin lymphoma in patients ≤ 18 years of age. We analyzed data from childhood and adolescent patients with stage III MLBL (n = 42) and non-MLBL DLBCL (n = 69) treated with Group B therapy in the French-American-British/Lymphome Malins de Burkitt (FAB/LMB) 96 study. MLBL patients had a male/female 26/16; median age, 15...
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Pediatric health research and development (R&D) has long lagged behind health R&D for adults. Methodological and ethical challenges associated with pediatric research increase the costs of running pediatric trials, and the market for pediatric products is relatively small. The subsequent knowledge gaps and lack of child-specific product development have resulted in high off-label and unlicensed...
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عنوان ژورنال:
- Blood
دوره 121 2 شماره
صفحات -
تاریخ انتشار 2013